Visualizing early steps in endosomal maturation
See paper by Zoncu et al., Cell. 2009 Mar 20;136(6):1110-21. www.cell.com Internalization of cell surface receptors is followed by their transport to endosomes. A subpopulation of endosomes defined by the presence of the protein APPL, a Rab 5 effector, has a specialized role in propagating signaling of internalized receptors. Here, macropinosomes (arrowheads) generated from membrane ruffles and marked by PI3P (green) are shown to subsequently shed PI3P, and this loss is closely followed by ...
Science & Technology
See original: Visualizing early steps in endosomal maturation