World Association of Young Scientists

sandygautam: RT @TheSocialBrain: {RiskTaking Teens Have More Mature Brains} Neuroscience study, diffusion tensor imaging: http://bit.ly/3K0t0z

See original: RT @TheSocialBrain: {RiskTaking Teens Have More Mature Brains} Neuroscience study, diffusion tensor imaging: http://bit.ly/3K0t0z

EvoMRI: Liked "Kissing was developed 'to spread germs' It isn't the most romantic theory, but scientists believe..." [pic] http://ff.im/aUajZ

See original: Liked "Kissing was developed 'to spread germs' It isn't the most romantic theory, but scientists believe..." [pic] http://ff.im/aUajZ

sandygautam: @asuph 'desire to try something new' esp something as complex as Wave: 'Confirmed Geek' (no perceivedgeek) @d7y @Palsule

See original: @asuph 'desire to try something new' esp something as complex as Wave: 'Confirmed Geek' (no perceivedgeek) @d7y @Palsule

EvoMRI: Liked "Observing biological dynamics at atomic resolution using NMR." http://ff.im/aUK7w

See original: Liked "Observing biological dynamics at atomic resolution using NMR." http://ff.im/aUK7w

EvoMRI: Thanks - they have the "free webinar" scheme that probably fits my needs:... re: http://ff.im/aGlbY

See original: Thanks - they have the "free webinar" scheme that probably fits my needs:... re: http://ff.im/aGlbY

Nicholas Negroponte of OLPC

This morning I woke up to find an e-mail in my inbox which contained a link to an xeconomy.com interview with Nicholas Negroponte. While reading it over breakfast I managed to spill my tea because I couldn't believe I was really seeing the words I was looking at. XO-2 development canceled? An XO-1.75 to replace it? Talk about an XO-3? Going from OLPC to olpc? But let's take it step by step, shall we...

From XO-2 to XO-1.75 to XO-3

NN: 2.0 has been replaced by two things: 1) model 1.75, same industrial design but an ARM inside, 2) model 3.0, totally different industrial design, more like a sheet of paper.

See original: Negroponte: XO-1.75 goes ARM, XO-2 is canceled

EvoMRI: Liked "A marvellous hummingbird display" http://ff.im/aUIxe

See original: Liked "A marvellous hummingbird display" http://ff.im/aUIxe

EvoMRI: Morpho-tools - a repository of morphometric tools and online morphometric workbenches http://ff.im/aUH1H

See original: Morpho-tools - a repository of morphometric tools and online morphometric workbenches http://ff.im/aUH1H

We trawl the world's journals so you don't have to:

Precursors and diverse pathways to personality disorder in children and adolescents (Development and Psychopathology).

The Society for Neuroscience, forty-year anniversary retrospective (Journal of Neuroscience).

Motivational interviewing and psychotherapy (Journal of Clinical Psychology).

Environmental psychology on the move (Journal of Environmental Psychology).

Spatial working memory and imagery: From eye movements to grounded cognition (Acta Psychologica).

Individual differences in emotion components and dynamics (Cognition and Emotion).

See original: The Special Issue Spotter

EvoMRI: Liked "El origen y la función común de la comunicación madre-hijo en primates y en humanos" http://ff.im/aUEYD

See original: Liked "El origen y la función común de la comunicación madre-hijo en primates y en humanos" http://ff.im/aUEYD

As I continue to catch up on my articles, this post is about an article by Rambold and colleagues that was published in the Journal of Neurochemistry.  The researchers’ study was designed to identify compounds that would interfere with the propagation of the pathologic prion protein.  The two compounds investigated in the present article were the main components of green tea, epigallocatechin gallate (EGCG) and gallocatechin gallate (GCG).  This was an in vitro study that used scrapie-infected N2a (ScN2a) cells.  Both EGCG and GCG reduced pathological prion protein in addition to decreasing native prion proteins.  In comparison to similar compounds, the authors found that the gallate side chain was necessary for antiprion activity and that an additional hydroxyl group of the trihydroxyphenyl side chain increased depletion of native prion proteins.  Their data also indicated that EGCG induced a conformational change in the native prion protein at the plasma membrane that resulted in a transitional conformation that led to internalization and lysosomal degradation.  Thus native prion proteins were depleted which also resulted in a reduction of the pathologic prion proteins. An interesting side point was that EGCG decreased the stress-protective function of the native prion protein in uninfected cells.  EGCG-treated cells showed an increased vulnerability to stressful conditions (i.e., subjected to excitotoxin kainate, an apoptotic agent)  In summary, EGCG and GCG induces a conformation change of the native prion protein that causes it to be internalized and degraded, thereby decreasing its conversion to pathologic prion protein.  In this process, the stress-protective activities of the native prion protein are diminished.  Once again, the conundrum of pathologic function +/- loss of function questions emerge as the etiologic cause of  the neuropathologic process in prion diseases.  Rambold, A., Miesbauer, M., Olschewski, D., Seidel, R., Riemer, C., Smale, L., Brumm, L., Levy, M., Gazit, E., Oesterhelt, D., Baier, M., Becker, C., Engelhard, M., Winklhofer, K., & Tatzelt, J. (2008). Green tea extracts interfere with the stress-protective activity of PrP and the formation of PrP Journal of Neurochemistry, 107 (1), 218-229 DOI: 10.1111/j.1471-4159.2008.05611.x   del.icio.us Tags: prion,biology,research,biochemistry...

See original: Components of green tea interfere with the physiologic role of the native prion protein and its conversion into the pathologic prion protein

EvoMRI: Liked "Promises, Promises :The Scientist" http://ff.im/aUlKj

See original: Liked "Promises, Promises :The Scientist" http://ff.im/aUlKj

EvoMRI: Liked "RT @tweetmeme BMJ Group blogs: BMJ » Richard Smith: The beginning of the end for impact factors and j......" http://ff.im/aUheO

See original: Liked "RT @tweetmeme BMJ Group blogs: BMJ » Richard Smith: The beginning of the end for impact factors and j......" http://ff.im/aUheO

EvoMRI: Liked "Introduction to Scholarly Research Videos < Video Playlist | Embedr" http://ff.im/aTLl1

See original: Liked "Introduction to Scholarly Research Videos &lt; Video Playlist | Embedr" http://ff.im/aTLl1

EvoMRI: Liked "Review: Historian Andrew Dalby chronicles Wikipedia, its philosophy, people and headlines" http://ff.im/aUBhH

See original: Liked &quot;Review: Historian Andrew Dalby chronicles Wikipedia, its philosophy, people and headlines&quot; http://ff.im/aUBhH