World Association of Young Scientists

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Member Profile

Academic Level

Post-Doc

Position

Research Associate

Working Sector

Secondary School / College / University

Highest Degree

Ph. D.

Discipline

Life Sciences: Physiology

Reseach Topic

Diabetes and Obesity Research

Publications

Ahmed, O.M.; Abdel-Moneim, A.; Abulyazid, I.; Mahmoud, A. M. (2010): Antihyperglycemic, antihyperlipidemic and antioxidant effects and the probable mechanisms of action of Ruta graveolens and rutin in Nicotinamide/streptozotocin diabetic albino rats. Diabetologia Croatica, 39- 1; 15: 32.

Mahmoud, A. M. (2011): Influence of rutin on biochemical alterations in hyperammonemia in rats. Experimental and Toxicologic Pathology, doi:10.1016/j.etp.2011.01.016.

Ahmed, O. M.; Mahmoud, A. M.; Abdel-Moneim, A. and Ashour, M. B. (2011): Antihyperglycemic and antihyperlipidemic effects of hesperidin and naringin in high fat diet/streptozotocin type 2 diabetic rats. Life Science, 8(4): 91-101.

Abdel-Moneim, A.; Ashour, M. B.; Mahmoud, A. M. and Ahmed, O. M. (2011): Insulin sensitizing effects of hesperidin and naringin in experimental model of induced type 2 diabetes: focus on tumor necrosis factor-alpha and resistin. Nature and Science, 9(10): 134-141.

Ahmed, O.M.; Afify, A.; Tarek M. Ali; Ramadan, S. A. and Mahmoud, A. M. (2012): Ameliorative Effects of Sildenafil in Acetic Acid-Induced Chronic Colitis in Rats. Life Science Journal, 9(1): 354-361.

Ahmed, O. M.; Mahmoud, A. M.; Abdel-Moneim, A. and Ashour, M. B. (2012): Antidiabetic effects of hesperidin and naringin in type 2 diabetic rats. Diabetologia Croatica. In Press.

Mahmoud, A. M.; Ahmed, O. M.; Ashour, M. B. and Abdel-Moneim, A. (2012): Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/strptozotocin-induced type 2 diabetic rats. Journal of Diabetes and its Complications. 10.1016/j.jdiacomp.2012.06.001.

Mahmoud, A. M.; Ahmed, O. M.; Ashour, M. B. and Abdel-Moneim, A. (2012): Hypoglycemic effects of hesperidin and naringin in high fat diet low dose strptozotocin type 2 diabetic rats: A study on the mechanism of action. Submitted to British Journal of Nutrition.

Ahmed, O. M.; Mahmoud, A. M.; Ashour, M. B. and Abdel-Moneim, A. (2012): Upregulation of PPARγ mediates the antidiabetic effects of citrus flavonoids in high fat diet fed-streptozotocin induced type 2 diabetic rats. Submitted to PPAR Research.

Ebaid, H.; Ahmed, O.M.; Mahmoud, A.M. and Ahmed, R.R. (2012): Whey protein ameliorates wound healing by modulation of the metabolic, immune and antioxidant systems. Journal of Diabetes and its Complications. In manuscript.

Research Tags

* Adipocytokines involved in insulin resistance, obesity and type 2 diabetes mellitus., * Molecular Mechanisms for Obesity and Diabetes, * Treatment of diabetes and its complications using natural products., * Neuroinflammation involvement in cell death in the CNS., * Search for natural PPAR panagonists and studying their therapeutic use for insulin resistance, type 2 diabetes mellitus, metabolic disorder and inflammatory neurological diseases.

Bio

Diabetes mellitus is a major risk factor for a number of chronic conditions, including cancer, cardiovascular disease, hypertension, renal failure and eye diseases and posses an enormous health care burden in developing and developed nations. Type 2 diabetes mellitus, the more prevalent type, is a worldwide epidemic with considerable health and economic consequences. The prevalence of type 2 diabetes mellitus is increasing worldwide. Risk factors for the development of diabetes include obesity, physical inactivity, hypertension, dyslipidaemia, family history, impaired glucose tolerance and impaired fasting glucose.
Obesity is well recognized as a fundamental leading cause of major health issues such as insulin resistance, diabetes, hyperlipidemia, cancer, hypertension, and cardiovascular diseases. Nevertheless, the molecular pathways which link obesity with such a wide spectrum of metabolic defects are not well understood. Adipose tissue is an active participant in controlling the body’s pathophysiological processes by releasing a variety of adipokines into blood stream. Many of these adipokines are directly or indirectly involved in the pathogenesis of obesity-related insulin resistance, type 2 diabetes and cardiovascular diseases.
Recently there has been a growing interest in hypoglycemic agents from natural products, especially those derived from plants, because plant sources are usually considered to be less toxic, with fewer side effects than synthetic sources. Accordingly, our current research focuses on the mechanisms underlying the pathogenesis of obesity-related insulin resistance and type 2 diabetes, especially the role of adipose tissue and its derived adipocytokines. We work on some plants used in folk medicine and some algae from the Red Sea to isolate and define novel compounds and using it in the treatment of obesity- related insulin resistance and type 2 diabetes along with its related complications. In addition we work to determine the exact mechanisms of action of the isolated compounds using the advanced techniques of molecular biology in determining the expression level of adipose tissue mediators. Evaluation of the effects of our proposed products on the previously mentioned variables may provide some novel therapeutic targets that will help patients plague with diabetes and its associated complications.
Note: Our current research project is funded by Science and Technology Development Fund (STDF {www.stdf.org.eg}).

General and Contact Information

Title

Dr.

First Name

Ayman

Last Name

Mahmoud

Date of Birth

09/11/1983

Country of Origin

Egypt

Country of Residence

Egypt

City

Beni-Suef

Languages

Arabic - English

History

Member for

48 weeks 5 days

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